rstpm2 - Smooth Survival Models, Including Generalized Survival Models

R implementation of generalized survival models (GSMs), smooth accelerated failure time (AFT) models and Markov multi-state models. For the GSMs, g(S(t|x))=eta(t,x) for a link function g, survival S at time t with covariates x and a linear predictor eta(t,x). The main assumption is that the time effect(s) are smooth <doi:10.1177/0962280216664760>. For fully parametric models with natural splines, this re-implements Stata's 'stpm2' function, which are flexible parametric survival models developed by Royston and colleagues. We have extended the parametric models to include any smooth parametric smoothers for time. We have also extended the model to include any smooth penalized smoothers from the 'mgcv' package, using penalized likelihood. These models include left truncation, right censoring, interval censoring, gamma frailties and normal random effects <doi:10.1002/sim.7451>, and copulas. For the smooth AFTs, S(t|x) = S_0(t*eta(t,x)), where the baseline survival function S_0(t)=exp(-exp(eta_0(t))) is modelled for natural splines for eta_0, and the time-dependent cumulative acceleration factor eta(t,x)=\int_0^t exp(eta_1(u,x)) du for log acceleration factor eta_1(u,x). The Markov multi-state models allow for a range of models with smooth transitions to predict transition probabilities, length of stay, utilities and costs, with differences, ratios and standardisation.

Last updated 30 days ago

11.10 score 28 stars 47 packages 140 scripts 9.5k downloads

etm - Empirical Transition Matrix

The etm (empirical transition matrix) package permits to estimate the matrix of transition probabilities for any time-inhomogeneous multi-state model with finite state space using the Aalen-Johansen estimator. Functions for data preparation and for displaying are also included (Allignol et al., 2011 <doi:10.18637/jss.v038.i04>). Functionals of the Aalen-Johansen estimator, e.g., excess length-of-stay in an intermediate state, can also be computed (Allignol et al. 2011 <doi:10.1007/s00180-010-0200-x>).

Last updated 3 years ago

7.88 score 11 packages 81 scripts 5.7k downloads

ascii - Export R Objects to Several Markup Languages

Coerce R object to 'asciidoc', 'txt2tags', 'restructuredText', 'org', 'textile' or 'pandoc' syntax. Package comes with a set of drivers for 'Sweave'.

Last updated 10 months ago

5.29 score 7 stars 2 packages 163 scripts 1.4k downloads

microsimulation - Discrete Event Simulation in R and C++, with Tools for Cost-Effectiveness Analysis

Discrete event simulation using both R and C++ (Karlsson et al 2016; <doi:10.1109/eScience.2016.7870915>). The C++ code is adapted from the SSIM library <https://www.inf.usi.ch/carzaniga/ssim/>, allowing for event-oriented simulation. The code includes a SummaryReport class for reporting events and costs by age and other covariates. The C++ code is available as a static library for linking to other packages. A priority queue implementation is given in C++ together with an S3 closure and a reference class implementation. Finally, some tools are provided for cost-effectiveness analysis.

Last updated 3 months ago

cppdiscrete-event-simulationhealth-economics

4.33 score 36 stars 20 scripts 293 downloads

biostat3 - Utility Functions, Datasets and Extended Examples for Survival Analysis

Utility functions, datasets and extended examples for survival analysis. This extends a range of other packages, some simple wrappers for time-to-event analyses, datasets, and extensive examples in HTML with R scripts. The package also supports the course Biostatistics III entitled "Survival analysis for epidemiologists in R".

Last updated 27 days ago

4.29 score 5 stars 98 scripts 840 downloads

brm - Binary Regression Model

Fits novel models for the conditional relative risk, risk difference and odds ratio.

Last updated 4 years ago

2.68 score 1 stars 24 scripts 326 downloads

magree - Implements the O'Connell-Dobson-Schouten Estimators of Agreement for Multiple Observers

Implements an interface to the legacy Fortran code from O'Connell and Dobson (1984) <DOI:10.2307/2531148>. Implements Fortran 77 code for the methods developed by Schouten (1982) <DOI:10.1111/j.1467-9574.1982.tb00774.x>. Includes estimates of average agreement for each observer and average agreement for each subject.

Last updated 10 months ago

2.30 score 8 scripts 238 downloads

nltm - Non-Linear Transformation Models

Fits a non-linear transformation model ('nltm') for analyzing survival data, see Tsodikov (2003) <doi:10.1111/1467-9868.00414>. The class of 'nltm' includes the following currently supported models: Cox proportional hazard, proportional hazard cure, proportional odds, proportional hazard - proportional hazard cure, proportional hazard - proportional odds cure, Gamma frailty, and proportional hazard - proportional odds.

Last updated 3 years ago

2.00 score 1 scripts 241 downloads